Product category:
Pharmaceutical Processing News
News Release from: Activotec | Subject: Peptide and protein production
Edited by the Processingtalk Editorial
Team on 30 August 2006
Peptide and protein production for
therapeutic use
Activotec has an extensive on-going R and D programme targeted at developing novel methods for the modification and production of peptides and proteins for therapeutic use
Activotec has an extensive on-going R and D programme targeted at developing novel methods for the modification and production of peptides and proteins for therapeutic use The developed patented methods are available for use in contract research and development programs with pharmaceutical, biotechnology and clinical organisations
This article was originally published on Processingtalk on 12 Feb 2007 at 8.00am (UK)
Related stories
Supercritical Fluid Extraction in pilot processing
The SFT-250 Supercritical Fluid Extraction / Reaction processing system from Activotec is designed to perform extractions and run reactions in a range of supercritical fluid media under pressure
Free Risk Assessment Service aims to avoid EPWs
Food safety scares and their associated 'Emergency Product Withdrawals' continue to make the headlines - whether it's contaminated salmon in the UK or suspect peanut butter in the US
Using an alkoxysilyl moiety as a temporary carboxyl-protecting group, Activotec has been able to offer highly efficient N- to C- directed solid-phase peptide synthesis.
The important advantage of the company's novel synthetic strategy is that it allows the preparation of peptide analogues possessing C-terminal modifications (such as esters, thioesters and alcohols) and peptides possessing peptide bond modifications (such as reduced peptide bonds, urea and isosteres) in the solid phase.
N- to C- synthesis has also been utilised to create amino acid analogues in which the carboxyl group is replaced with a diol functionality.
Further reading
Impurities in Active Pharmaceutical Ingredients
ESA Biosciences describes how the Corona Charged Aerosol Detector (CAD) enables the routine measurement of low-nanogram levels of organic impurities in Active Pharmaceutical Ingredients (APIs)
Automatic weighing solution for fresh meat
Ishida Europe has extended its range of solutions for the weighing and packing of fresh, sticky products with the introduction of a new range of 'Screw Feed' multi-head weighers
This group acts as unique masking group for the sequential ligation of peptide fragments, for the synthesis of artificial proteins, and in the generation of peptide-aldehydes, an important class of peptide/protein therapeutics.
Other potential applications for the Activotec novel N- to C- directed solid-phase synthesis methodology include protease resistance, drug delivery tools, vaccine design and peptide-drug conjugates.
In 2005 Activotec was granted a BBSRC research grant of GBP160,000 over two years.
The company is currently developing a novel method for the de novo synthesis of therapeutic proteins to chemical standards of purity not attainable by recombinant means.
The new methodology will employ polyethylene glycol as a temporary solubilising agent in the sequential chemical ligation of synthetic peptide fragments to allow the economic synthesis of commercially important therapeutic proteins/peptides (calcitonin, exenatide, beta-amyloid, eotaxin, GM-CSF, and IL-2).
Activotec, which has its trading base in Cambridge (UK) and an R and D and production facility in Southampton (UK), was founded in 2002 as a spin out from the internationally renowned School of Biological Sciences at the University of Southampton.
Activotec is a customer-focused company providing high technology products and services for chemistry and biochemistry applications.
Activotec provides a complete range of products and services for peptide and protein synthesis.
For further information on Activotec contract research and development services for the modification and production of peptides and proteins for therapeutic use please contact us.
• Activotec: contact details and other news
• Email this article to a colleague
• Register for the free Processingtalk email newsletter
• Processingtalk Home Page
Search the Pro-Talk network of sites
