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Pharmaceutical Processing News
News Release from: Hosokawa Micron | Subject: Stirred freeze drying
Edited by the Processingtalk Editorial
Team on 09 February 2006
New stirred freeze drying technology
New stirred freeze drying technology, for even the most sensitive and precious products, removes the liquid without changing the product structure: ideal for pro-biotics and pharmaceuticals
available from Hosokawa Micron is set to revolutionise freeze drying of even the most sensitive and precious products with a single step, solid to gas stage, which removes the liquid without changing the product structure Ideal for drying applications such as the production of pro-biotics, pharmaceuticals and nano-materials where demand for pristine, undamaged final product is essential, stirred freeze drying offers final products with good shelf stability and which remain unchanged after reconstitution
This article was originally published on Processingtalk on 10 Jan 2008 at 8.00am (UK)
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Conventional freeze drying systems, of the tray dryer type, are typically slow, with a low heat transfer rate due to stationary material and are manually intensive as trays of material have to be filled and discharged by hand.
In this type of drying often the product layer forms a single piece of hard baked material which has to be crushed after freeze drying and this step can lead to damage of the product structure.
The Hosokawa Micron stirred freeze drying technology which incorporates the use of a jacketed and stirred, Vrieco-Nauta, conical vacuum dryer operated at low temperature and pressure, produces a lump free, free flowing, freeze dried product.
As the material is constantly in motion stirred freeze drying offers increased heat transfer rates which shortens the drying time.The final freezing stage is simplified because it can be done in the same vessel instead of having to transfer the product to a separate freezing unit, making the process much less manually intensive than the conventional tray drying method.
Stirred freeze drying can be operated continuously with dry particles, released from the frozen material during the drying process, collected in a filter alongside the actual dryer.
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