Product category:
Powder, droplet and particle characterisation
News Release from: Malvern Instruments | Subject: Spraytec
Edited by the Processingtalk Editorial
Team on 13 June 2006
Measuring pharmaceutical nasal spray
droplet size
Researchers at Valois Pharmaceuticals are using a Malvern Instruments Spraytec system to develop robust droplet size test methods for quality control and product development applications
Researchers at Valois Pharmaceutical Division, a leader in the design and manufacture of spray delivery systems, are using a Malvern Instruments Spraytec system to develop robust droplet size test methods for quality control and product development applications The Spraytec provides a routine method of verifying the batch-to-batch product consistency of the different nasal pump delivery systems produced by Valois, in line with recently proposed FDA guidelines
This article was originally published on Processingtalk on 11 Aug 2008 at 8.00am (UK)
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Spraytec in routine use by Melbourn Scientific
Melbourn Scientific has become the first CRO in the UK to routinely use the Malvern Instruments Spraytec particle size analyser to support the development of inhaler, nebuliser and nasal spray systems
The design of new delivery systems can also be optimised.
Spray droplet data has been especially useful in the development and performance testing of Equadel, a new nasal spray pump designed to generate user-independent performance.
Spray droplet data collected using automated actuation stations illustrate how droplet size, a key variable in defining drug bio-availability, can vary with actuation profile.
Normally significant changes in pump output are observed as the actuation profile is changed.
However, data generated using the Spraytec confirms that Equadel pump system is insensitive to the applied actuation profile, as was the design intent.
This new design will therefore be more consistent, in terms of delivery performance, from patient-to-patient.
Spray characterisation, such as spray droplet size measurement, has become routine in the testing of nasal spray products and devices.
For production quality control purposes FDA guidelines recommend that a certain number of devices from each batch are tested prior to despatch.
Spraytec, a laser diffraction system, specifically designed to meet industrial requirements for the efficient measurement of spray droplet size, is proving to be highly effective in this application. Request a free brochure from Malvern Instruments ...
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