Product category:
Liquid Analysis: DO, Ozone, BOD, TOC
News Release from: Mettler Toledo | Subject: InPro 6880i
Edited by the Processingtalk Editorial
Team on 16 January 2008
Optical oxygen sensors for enhanced
performance
The innovative Mettler Toledo optical DO sensors for biopharmaceutical processes are fully steam-sterilisable, and combine accuracy and signal stability with fast response time
During fermentation processes, air feed and agitator speed are adjusted on the basis of the measured DO concentration value in order to achieve optimal growth conditions for the micro-organisms Indeed, excessive air feed can even damage the cells, besides leading to wastage of energy by the compressor
This article was originally published on Processingtalk on 5 Jun 2008 at 8.00am (UK)
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It is precisely in the case of batch runs of up to 5 weeks that the optical oxygen sensor can here fully demonstrate their inherent strength, namely negligible drift over time.
The stable measurement enables batch-to-batch consistency and the maintenance of optimal growth conditions.
The new optical oxygen sensor InPro 6880i from Mettler Toledo can be used in small, autoclavable research bioreactors as well as in full production-scale vessels.
The identical characteristic in both cases facilitates and accelerates scale-up.
At the heart of the optical sensor lies the oxygen-sensitive layer which contains immobilised marker molecules.
These molecules respond to light by means of a chemo-optical mechanism which is influenced by the amount of oxygen diffusing into the layer.
This effect allows determining the oxygen concentration in the sample media.
The measurement technology of these optical oxygen sensors is designed to meet the most exacting demands.
The 12 mm / Pg13.5 sensors are fully sterilisable and autoclavable.
They offer reliable measurement accuracy and signal stability, ideal for biopharmaceutical process control.
They fulfill the highest pharmaceutical requirements such as N5 / Ra16 (Ra0.4um / 16um) surface finish, sanitary design, FDA approval, and USP Class VI certified seals.
Optical technology does not need any electrolyte solution and therefore simplifies handling.
The built-in "Intelligent Sensor Management" (ISM) technology allows for quick start-up with "Plug and Measure" functionality, and offers advanced diagnostics.
The smart digital communication between sensor and transmitter ensures reliability for better process control.
ISM helps in deciding whether a sensor is safe for re-use in the next batch or whether it is advisable to carry out maintenance such as membrane replacement.
The modular sensor design allows disconnecting the sensor shaft from the sensor head, which facilitates autoclaving handling and reduces maintenance effort and costs.
The robust O2 sensitive layer offers increased lifetime and allows fast and easy replacement.
Furthermore, the optical oxygen sensor offers maximum availability, since no polarisation time is required. Request a free brochure from Mettler Toledo ...
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