Product category:
Liquid Analysis: Titration, HPLC, IC
News Release from: Thermo Fisher Scientific (Chromatography) | Subject: Melamine moitoring
Edited by the Processingtalk Editorial
Team on 17 August 2007
Method for detecting melamine residues
in fish
Thermo Fisher Scientific announces that a new method to detect melamine content in catfish has been developed by the US FDA, after the recent discovery of contamination from imported food sources
The method uses Thermo Scientific instrumentation for a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) solution, and is published in the US Food and Drug Administration (FDA) Laboratory Information Bulletin Nr 4396, "Determination of Melamine Residues in Catfish Tissue by Triple Quadrupole LC-MS/MS with HILIC Chromatography" Recent news coverage about the presence of melamine - an industrial chemical used in the manufacturing of plastics, flame retardants and other products - in pet food, animal feed, wheat gluten and other protein-based food commodities has raised the general public's concern about the chemical in the food supply chain for both animals and humans
This article was originally published on Processingtalk on 30 Jun 2008 at 8.00am (UK)
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According to the bulletin, "because animals may eat food contaminated with melamine residues, there is a need for analytical methods to determine melamine residues that may be present in animal tissues".
The FDA performed the LC-MS/MS method using the Thermo Scientific TSQ Quantum triple quadrupole mass spectrometer coupled to a Thermo Scientific Surveyor MS pump and autosampler.
Additionally, Thermo Scientific Xcalibur data system software was used to acquire and analyse the data.
The FDA method showed that the Thermo Scientific instrumentation detected melamine at levels of 10 parts per billion in catfish extract, thereby exceeding the agency requirements.
Melamine is not approved for use in food or animal feed.
Contaminated vegetable proteins imported into the United States from China were found to be used as ingredients in pet food, which sparked a nationwide pet food recall that began March 15, 2007.
Additionally, a portion of the tainted pet food was used to produce farm animal feed and fish feed.
The FDA and the US Department of Agriculture discovered that some animals that ate the tainted feed had been processed into human food.
The Thermo Scientific TSQ Quantum triple quadrupole system is the only instrument that enables Highly Selective Reaction Monitoring (H-SRM), which facilitates the quick and efficient analysis of complex samples such as animal tissue.
The Thermo Scientific LC-MS/MS solution yielded accuracy and precision values for this method that were well within the guidelines of the FDA for analytical method development and validation.
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