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Pharmaceutical Processing News
News Release from: Thermo Fisher Scientific (Molecular Spectroscopy) | Subject: Antaris target blend analyser
Edited by the Processingtalk Editorial
Team on 03 October 2006
Pharmaceutical tablet blend analyser
The Antaris target blend analyser is designed to meet the needs of scientists working in pharmaceutical and biopharmaceutical R+D, to monitor tablet manufacturing blending processes
Thermo's Antaris Target Blend Analyzer Wins Best Micro- and Nanotechnologies 2006 Award Thermo Electron Corporation, world leader in analytical instrumentation, announces that its Antaris Target blend analyser has been named as one of the 25 best micro- and nano-technologies introduced into the marketplace in 2006 This award selects those products, processes, inventions and discoveries that are the most innovative and most groundbreaking and that are likely to have the largest impact on their industry or society
This article was originally published on Processingtalk on 5 Jun 2008 at 8.00am (UK)
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Specifically designed to meet the needs of scientists working in pharmaceutical and biopharmaceutical research and development, pharmaceutical manufacturing and Process Analytical Technology (PAT), the Thermo Antaris Target near-infrared (NIR) blend analyser enables real-time monitoring of tablet manufacturing blending processes.
The blending of powders for tablet production ensures that all tablets made from the batch contain the target amount of active and other ingredients.
Insufficient or too much blending results in non-uniformity of tablets and a significant loss of funds.
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Traditionally, the testing of pharmaceutical blends has been done by manually collecting up to 30 samples per batch and sending them to the laboratory for HPLC or other testing for uniformity.
However, this testing exposes operators to high potency drugs, is not likely to detect common blend problems, is time-consuming and expensive and there is the possibility of interference with blend uniformity.
The Thermo Antaris Target blend analyser mounts directly onto pilot and production scale blending equipment in the laboratory, facilitating process endpoint determination, blend uniformity verification and blend problem detection in real-time.
The system works by collecting a near-infrared diffuse reflectance spectrum of powder through a window in the powder bin.
It can be optically optimised for different dosages and can determine blending endpoint without calibration.
Additionally, it achieves the highest available resolution measurements for accurate endpoint determination as well as concentration measurements using switch-free automatic data acquisition.
The combination of one-piece design, compact size, easy mounting mechanism, wireless communications and internal rechargeable battery capability of the Antaris Target blend analyser allows it to be quickly and easily moved from one blender to another, maximising its utility and return on investment.
The Antaris Target blend analyser provides a complete solution in a Good Manufacturing Practice (GMP) manufacturing setting.
Using Micro-Electro-Mechanical Systems (MEMS) technology, the analyser provides high spectral resolution and analyte specificity, continuous source output over battery life, 20+ year reliability and continuous internal wavelength and photometric self-calibration.
Internal backgrounds/referencing allow instrument referencing while the system is on the blender.
Data trigger positions are easily set in the software, enabled by the patent-pending use of accelerometer electronics that determine the position of the analyser in the rotation cycle.
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